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Hypnozoites in Plasmodium: Do Parasites Parallel Plants?
Trends in Parasitology ( IF 9.6 ) Pub Date : 2020-11-27 , DOI: 10.1016/j.pt.2020.11.001
Catherine J Merrick 1
Affiliation  

The phenomenon of relapsing malaria has been recognised for centuries. It is caused in humans by the parasite species Plasmodium vivax and Plasmodium ovale, which can arrest growth at an early, asymptomatic stage as hypnozoites inside liver cells. These dormant parasites can remain quiescent for months or years, then reactivate causing symptomatic malaria. The dynamics of hypnozoite dormancy and reactivation are well documented but the molecular basis remains a complete mystery. Here, I observe that the process has striking parallels with plant vernalisation, whereby plants remain dormant through the winter before flowering in spring. Vernalisation is thoroughly studied in several plant species and its mechanisms are known in exquisite detail. Vernalisation may thus provide a useful framework for interrogating hypnozoite biology.



中文翻译:

疟原虫中的休眠体:寄生虫与植物平行吗?

几个世纪以来,人们已经认识到疟疾复发的现象。它是由寄生虫物种间日疟原虫卵形疟原虫在人类中引起的,它可以在早期无症状阶段阻止生长,成为肝细胞内的休眠体。这些休眠的寄生虫可以保持静止数月或数年,然后重新激活引起有症状的疟疾。休眠体休眠和重新激活的动力学有据可查,但分子基础仍然是一个完整的谜。在这里,我观察到这个过程与植物春化有着惊人的相似之处,即植物在春天开花之前整个冬天都处于休眠状态。春化作用在几个植物物种中得到了彻底的研究,其机制非常详细。因此,春化作用可以为研究休眠体生物学提供一个有用的框架。

更新日期:2020-11-27
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