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Drosophila Mechanosensory Transduction
Trends in Neurosciences ( IF 15.9 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.tins.2020.11.001
Philip Hehlert 1 , Wei Zhang 2 , Martin C Göpfert 3
Affiliation  

Mechanosensation in Drosophila relies on sensory neurons transducing mechanical stimuli into ionic currents. The molecular mechanisms of this transduction are in the process of being revealed. Transduction relies on mechanogated ion channels that are activated by membrane stretch or the tension of force-conveying tethers. NOMPC (no-mechanoreceptor potential C) and DmPiezo were put forward as bona fide mechanoelectrical transduction (MET) channels, providing insights into MET channel architecture and the structural basis of mechanogating. Various additional channels were implicated in Drosophila mechanosensory neuron functions, and parallels between fly and vertebrate mechanotransduction were delineated. Collectively, these advances put forward Drosophila mechanosensory neurons as cellular paradigms for mechanotransduction and mechanogated ion channel function in the context of proprio- and nociception as well as the detection of substrate vibrations, touch, gravity, and sound.

中文翻译:

果蝇机械感应转导

果蝇的机械感觉依赖于将机械刺激转化为离子电流的感觉神经元。这种转导的分子机制正在被揭示。转导依赖于由膜拉伸或力传递系绳的张力激活的机械化离子通道。NOMPC(无机械感受器电位 C)和 DmPiezo 被提出作为真正的机械电转导 (MET) 通道,提供了对 MET 通道结构和机械控制结构基础的见解。果蝇机械感觉神经元功能中涉及各种额外的通道,并描绘了苍蝇和脊椎动物机械转导之间的相似之处。总的来说,
更新日期:2020-11-01
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