BELAVY, D. L., J. Van Oosterwijck, M. Clarkson, E. Dhondt, N. L. Mundell, C. Miller and P. J. Owen. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2020. Exercise training is capable of reducing pain in chronic pain syndromes, yet its mechanisms are less well established. One mechanism may be via the impact of exercise on increasing a person's pain threshold. Here we show, via meta-analysis of fifteen exercise training studies in pain syndromes that exercise training leads to increased pressure pain thresholds (low to moderate quality evidence). We also find low to moderate quality evidence exists that exercise training was more effective than non-exercise interventions, such as pain education, massage and stress management for improving pain sensitivity. Further, the effect of exercise was greater locally at the site of pain and less so at remote regions. These finding suggest that adaptations in central inhibition occur over time with exercise training and, more widely, add to the mechanistic understanding of how effective interventions can improve pain in chronic pain syndromes.

BELAVY，DL，J.Van Oosterwijck，M.Clarkson，E.Dhondt，NL Mundell，C.Miller和PJ Owen。NEUROSCI BIOBEHAV REV 21（1）XXX-XXX，2020年。运动训练能够减轻慢性疼痛综合症的疼痛，但其机制尚不完善。一种机制可能是通过锻炼对增加人的疼痛阈值的影响。在这里，我们通过对15种疼痛综合征的运动训练研究的荟萃分析表明，运动训练导致压力痛阈值增加（低至中等质量的证据）。我们还发现，中低质量的证据表明，运动训练比非运动干预更有效，例如疼痛教育，按摩和压力管理以改善疼痛敏感性。进一步，运动的效果在疼痛部位局部较大，而在偏远地区则较小。这些发现表明，随着锻炼的进行，中枢抑制的适应性随着时间的流逝而发生，并且更广泛地增加了对有效干预措施如何改善慢性疼痛综合征疼痛的机制的理解。