Flower-like metal-organic frameworks (Cu-MOF) nanoparticles are successfully synthesized and incorporated into cellulose acetate (CA) matrix to prepare CA-based functional nanocomposite films via a simple solution-casting method. The effect of the incorporation of flower-like Cu-MOF on the morphological, mechanical, thermal, surface wettability, water vapor barrier, cytotoxicity, photostability and UV-shielding properties of CA films is fully investigated. Results reveal that the flower-like Cu-MOF has good compatibility with CA, providing uniform and compact nanocomposite films. The as-prepared nanocomposite films show improved mechanical properties, surface hydrophobicity, water vapor barrier ability compared to neat CA film, and exhibit super UV-shielding capability through the entire UV regions meanwhile retaining a high visible transparency. Moreover, the high transparency and UV-shielding ability of the nanocomposite films can be still maintained even after continuous UV-light (365 nm) irradiation for 12 h. In addition, MTT cytotoxicity assays towards normal human liver cells (HL-7702) reveal high cell viability (over 80%) and good biocompatibility for the CA/Cu-MOF nanocomposite films. These results indicate that the CA/Cu-MOF nanocomposite films with obviously improved physical and functional performances hold significant potential for transparent packaging and UV-protection applications.

成功地合成了花状金属有机骨架（Cu-MOF）纳米粒子，并将其掺入醋酸纤维素（CA）基质中，以通过简单的溶液浇铸方法制备基于CA的功能性纳米复合薄膜。充分研究了掺入花状Cu-MOF对CA膜的形态，机械，热，表面润湿性，水蒸气阻隔性，细胞毒性，光稳定性和紫外线屏蔽性能的影响。结果表明，花状Cu-MOF与CA具有良好的相容性，可提供均匀且致密的纳米复合膜。与纯净的CA膜相比，所制备的纳米复合膜表现出改善的机械性能，表面疏水性，水蒸气阻隔能力，并在整个UV区域均显示出超强的UV屏蔽能力，同时保持了较高的可见透明性。此外，即使在连续紫外线（365 nm）照射12小时之后，纳米复合膜的高透明性和紫外线屏蔽能力仍然可以保持。此外，对正常人肝细胞（HL-7702）的MTT细胞毒性试验显示，CA / Cu-MOF纳米复合膜具有很高的细胞活力（超过80％）和良好的生物相容性。这些结果表明，具有明显改善的物理和功能性能的CA / Cu-MOF纳米复合膜在透明包装和紫外线防护应用方面具有巨大潜力。对正常人肝细胞（HL-7702）的MTT细胞毒性试验显示，CA / Cu-MOF纳米复合膜具有很高的细胞活力（超过80％）和良好的生物相容性。这些结果表明，具有明显改善的物理和功能性能的CA / Cu-MOF纳米复合膜在透明包装和紫外线防护应用方面具有巨大潜力。对正常人肝细胞（HL-7702）的MTT细胞毒性试验显示，CA / Cu-MOF纳米复合膜具有很高的细胞活力（超过80％）和良好的生物相容性。这些结果表明，具有明显改善的物理和功能性能的CA / Cu-MOF纳米复合膜在透明包装和紫外线防护应用方面具有巨大潜力。