Recent studies have suggested that Hippo signaling is not only involved in controlling organ size in Drosophila but can also regulate cell proliferation, tissue homeostasis, differentiation, apoptosis and regeneration. Any dysregulation of Hippo signaling, especially the hyper activation of its downstream effectors YAP/TAZ, can lead to uncontrolled cell proliferation and malignant transformation. In majority of cancers, expression of YAP/TAZ is extremely high and this increased expression of YAP/TAZ has been shown to be an independent predictor of prognosis and indicator of increased cell proliferation, metastasis and poor survival. In this review, we have summarized the most recent findings about the cross talk of Hippo signaling pathway with other signaling pathways and its regulation by different miRNAs in various cancer types. Recent evidence has suggested that Hippo pathway is also involved in mediating the resistance of different cancer cells to chemotherapeutic drugs and in a few cancer types, this is brought about by regulating miRNAs. Therefore, the delineation of the underlying mechanisms regulating the chemotherapeutic resistance might help in developing better treatment options. This review has attempted to provide an overview of different drugs/options which can be utilized to target oncogenic YAP/TAZ proteins for therapeutic interventions.

最近的研究表明，河马信号不仅涉及控制果蝇的器官大小但也可以调节细胞增殖、组织稳态、分化、凋亡和再生。Hippo 信号的任何失调，尤其是其下游效应子 YAP/TAZ 的过度激活，都可能导致不受控制的细胞增殖和恶性转化。在大多数癌症中，YAP/TAZ 的表达非常高，这种 YAP/TAZ 表达的增加已被证明是预后的独立预测因子，也是细胞增殖、转移和存活率增加的指标。在这篇综述中，我们总结了有关 Hippo 信号通路与其他信号通路的串扰及其在各种癌症类型中受不同 miRNA 调节的最新发现。最近的证据表明，Hippo 通路还参与介导不同癌细胞对化疗药物的耐药性，并且在一些癌症类型中，这是通过调节 miRNA 引起的。因此，描述调节化疗耐药性的潜在机制可能有助于开发更好的治疗方案。本综述试图概述不同的药物/选项，这些药物/选项可用于靶向致癌 YAP/TAZ 蛋白进行治疗干预。