Tripeptide H-Lys-Lys-Gly-OH was synthesized. Its toxic properties and biological activity were studied. The tripeptide was synthesized by extending the peptide chain from the C-terminus by synthesizing N², N⁶-dicarbobenzoxylysine [N²,N⁶-(Cbz)₂Lys] and N⁶-carbobenzoxylysine (N⁶-CbzLys) methyl ester hydrochloride and condensing them by the mixed anhydride method to produce the methyl ester of N²,N⁶-(Cbz)₂Lys-N⁶-CbzLys. The next step in the tripeptide synthesis consisted of obtaining glycine benzyl ester (Gly-OBzl) hydrochloride and condensing it with N²,N⁶-(Cbz)₂Lys-N⁶-CbzLys hydrazide to produce the protected target tripeptide Z-Lys(Z)-Lys-Gly-OBzl. The last step consisted of removing the protection using hydrogenolysis over Ni-Re catalyst. Test results showed that the synthesized tripeptide had low toxicity.

合成三肽H-Lys-Lys-Gly-OH。研究了它的毒性和生物学活性。通过合成N ²，N ^6-二碳代苄氧赖氨酸[ N ²，N ^6-（Cbz）₂ Lys]和N ^6-碳代苄氧赖氨酸（N ⁶ -CbzLys）甲酯盐酸盐，从C末端延伸肽链来合成三肽并通过混合酸酐法将其缩合以生成N ²，N ^6-（Cbz）₂ Lys- N ⁶的甲酯-CbzLys。三肽合成的下一步包括获得甘氨酸苄基酯（Gly-OBzl）盐酸盐并将其与N ²，N ^6-（Cbz）₂ Lys- N ⁶ -CbzLys酰肼缩合以生成受保护的目标三肽Z -Lys（Z）-Lys-Gly-OBzl。最后一步包括在Ni-Re催化剂上使用氢解作用去除保护层。试验结果表明，合成的三肽毒性低。