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Celastrol-mediated autophagy regulation in cancer
Applied Biological Chemistry ( IF 3.2 ) Pub Date : 2020-11-25 , DOI: 10.1186/s13765-020-00565-3
Muhammad Haroon , Sun Chul Kang

In the last few decades, studies on autophagy regulation and its potential role in cancer therapeutics have expanded to include detailed mechanisms. Since apoptosis exhibits drug resistance in some cancers, efforts have focused on searching for compounds with autophagy modulating properties. Numerous natural compounds have been used in cancer treatment and are considered a significant research area due to their remarkable anti-cancer properties. Celastrol, a quinone methide triterpene, derived from Tripterygium wilfordii, has recently drawn much attention because of its anticancer potential. It enhances tumor suppression and induces autophagy in cancer cells by regulating signaling pathways such as Beclin-1, Akt/mTOR, ROS, NF-κB, MAPK, HSP90, and the proteasome. In the current study, we address the anticancer potential of celastrol, its effect on various cellular pathways, and describe how it functions as an autophagy modulator in cancer therapeutics and helps diminish multidrug resistance in cancer cells.

中文翻译:

Celastrol介导的自噬调节癌症

在过去的几十年中,关于自噬调节及其在癌症治疗中的潜在作用的研究已经扩展到包括详细的机制。由于凋亡在某些癌症中表现出耐药性,因此人们致力于研究具有自噬调节特性的化合物。许多天然化合物已用于癌症治疗,由于其卓越的抗癌特性,被认为是重要的研究领域。Celastrol是一种源自雷公藤的甲基化醌三萜烯,最近因其具有抗癌潜力而备受关注。它通过调节Beclin-1,Akt / mTOR,ROS,NF-κB,MAPK,HSP90和蛋白酶体等信号通路,增强肿瘤抑制并诱导癌细胞自噬。在本研究中,我们探讨了Celastrol的抗癌潜力,
更新日期:2020-11-27
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