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Efficient and accessible silane-mediated direct amide coupling of carboxylic acids and amines
Green Chemistry ( IF 9.8 ) Pub Date : 2020-11-23 , DOI: 10.1039/d0gc02833a
Melissa C. D'Amaral 1, 2, 3, 4 , Nick Jamkhou 1, 2, 3, 4 , Marc J. Adler 1, 2, 3, 4
Affiliation  

A straightforward method for the direct synthesis of amides from amines and carboxylic acids without exclusion of air or moisture using diphenylsilane with N-methylpyrrolidine has been developed. Various amides are made efficiently, and broad functional group compatibility is shown through a Glorius robustness study. A gram-scale synthesis demonstrates the scalability of this method.

中文翻译:

高效且易于接近的硅烷介导的羧酸和胺类酰胺直接偶联

已经开发了使用二苯基硅烷与N-甲基吡咯烷酮直接从胺和羧酸直接合成酰胺而不排除空气或水分的简单方法。有效地制备了各种酰胺,通过Glorius稳健性研究显示了广泛的官能团相容性。克级合成证明了此方法的可扩展性。
更新日期:2020-12-17
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