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Design and Applications of Water-Soluble Coordination Cages
Chemical Reviews ( IF 62.1 ) Pub Date : 2020-11-25 , DOI: 10.1021/acs.chemrev.0c00672
Edmundo G Percástegui 1, 2, 3 , Tanya K Ronson 1 , Jonathan R Nitschke 1
Affiliation  

Compartmentalization of the aqueous space within a cell is necessary for life. In similar fashion to the nanometer-scale compartments in living systems, synthetic water-soluble coordination cages (WSCCs) can isolate guest molecules and host chemical transformations. Such cages thus show promise in biological, medical, environmental, and industrial domains. This review highlights examples of three-dimensional synthetic WSCCs, offering perspectives so as to enhance their design and applications. Strategies are presented that address key challenges for the preparation of coordination cages that are soluble and stable in water. The peculiarities of guest binding in aqueous media are examined, highlighting amplified binding in water, changing guest properties, and the recognition of specific molecular targets. The properties of WSCC hosts associated with biomedical applications, and their use as vessels to carry out chemical reactions in water, are also presented. These examples sketch a blueprint for the preparation of new metal–organic containers for use in aqueous solution, as well as guidelines for the engineering of new applications in water.

中文翻译:

水溶性协调笼的设计与应用

细胞内水空间的划分对于生命来说是必要的。与生命系统中的纳米级隔室类似,合成的水溶性配位笼(WSCC)可以隔离客体分子并进行化学转化。因此,这种笼子在生物、医学、环境和工业领域显示出前景。本综述重点介绍了三维合成 WSCC 的示例,提供了增强其设计和应用的观点。提出了解决制备可溶于水且稳定的配位笼的关键挑战的策略。研究了水介质中客体结合的特性,强调了水中结合的放大、客体特性的改变以及特定分子靶标的识别。还介绍了 WSCC 宿主与生物医学应用相关的特性,以及它们作为在水中进行化学反应的容器的用途。这些例子描绘了用于水溶液的新型金属有机容器的制备蓝图,以及水中新应用的工程设计指南。
更新日期:2020-12-23
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