Glufosinate-ammonium (GLA) is a broad-spectrum herbicide for agricultural weed control and crop desiccation. Due to many GLA-resistant crops being developed to effectively control weeds and increase harvest yields, herbicide usage and the residual GLA in food has increased significantly. Though perinatal exposure by the residual GLA in food might affect brain development, the developmental neurotoxicity of GLA is still unclear. Therefore, this study aimed to investigate the effects of perinatal exposure to GLA on cortical development. The analysis revealed that perinatal GLA exposure altered behavioral changes in offspring, especially motor functional behavior. Moreover, perinatal GLA exposure affected cortical development, particularly by disrupting interneuron migration. These results provide new evidence that early life exposure to GLA alters cortical development.

草铵膦（GLA）是一种广谱除草剂，用于控制农业杂草和作物干燥。由于开发了许多抗GLA的农作物来有效控制杂草并提高收成，因此除草剂的使用和食品中残留的GLA大大增加。尽管围产期食物中残留的GLA暴露可能会影响大脑发育，但仍不清楚GLA的发育神经毒性。因此，本研究旨在调查围产期暴露于GLA对皮质发育的影响。分析表明，围产期GLA暴露改变了后代的行为变化，尤其是运动功能行为。此外，围产期GLA暴露会影响皮层发育，特别是通过干扰神经元间迁移来影响皮层发育。