The current study aimed to evaluate the efficacy of linked color imaging (LCI) in improving the visibility of superficial non-ampullary duodenal epithelial tumors (SNADETs). We prospectively evaluated 44 consecutive patients diagnosed with SNADETs. Three trainees and three experts assessed the visibility scores of white light imaging (WLI), LCI, and blue laser imaging-bright (BLI-b) for SNADETs, which ranged from 1 (not detectable without repeated cautious examination) to 4 (excellent visibility). In addition, the L* a* b* color values and color differences (ΔE*) were evaluated using the CIELAB color space system. For SNADETs, the visibility scores of LCI (3.53 ± 0.59) were significantly higher than those of WLI and BLI-b (2.66 ± 0.79 and 3.41 ± 0.64, respectively). The color differences (ΔE*) between SNADETs and the adjacent normal duodenal mucosa in LCI mode (19.09 ± 8.33) were significantly higher than those in WLI and BLI-b modes (8.67 ± 4.81 and 12.92 ± 7.95, respectively). In addition, the visibility score of SNADETs and the color differences in LCI mode were significantly higher than those in WLI and BLI-b modes regardless of the presence of milk white mucosa (MWM). LCI has potential benefits, and it is considered a promising clinical modality that can increase the visibility of SNADETs regardless of the presence of MWM.

This study was registered at the University Hospital Medical Information Network (UMIN000028840).

当前的研究旨在评估链接彩色成像（LCI）在改善浅表非壶腹十二指肠上皮肿瘤（SNADET）的可见性方面的功效。我们前瞻性评估了44例连续诊断为SNADET的患者。三名学员和三名专家评估了SNADET的白光成像（WLI），LCI和蓝色激光成像-亮（BLI-b）的可见性评分，范围从1（无法反复仔细检查无法检测到）到4（出色的可见度） ）。此外，使用CIELAB色彩空间系统评估了L * a * b *颜色值和色差（ΔE*）。对于SNADET，LCI的可见度得分（3.53±0.59）明显高于WLI和BLI-b的可见度得分（分别为2.66±0.79和3.41±0.64）。在LCI模式下（19.09±8.33），SNADET与相邻的正常十二指肠粘膜之间的色差（ΔE*）显着高于WLI和BLI-b模式下的色差（分别为8.67±4.81和12.92±7.95）。此外，无论是否存在乳白色粘膜（MWM），SNADET的可见度得分和LCI模式下的色差均显着高于WLI和BLI-b模式下的可见度得分。LCI具有潜在的好处，并且被认为是一种有前途的临床方法，无论是否存在MWM，它都可以增加SNADET的可见性。SNADETs的可见度得分和LCI模式下的色差均显着高于WLI和BLI-b模式下的色差，无论是否存在乳白色粘膜（MWM）。LCI具有潜在的好处，并且被认为是一种有前途的临床方法，无论是否存在MWM，它都可以增加SNADET的可见性。无论是否存在乳白色粘膜（MWM），SNADET的可见度得分和LCI模式下的色差均显着高于WLI和BLI-b模式下的色差。LCI具有潜在的好处，并且被认为是一种有前途的临床方法，无论是否存在MWM，它都可以增加SNADET的可见性。

该研究在大学医院医学信息网络（UMIN000028840）上进行了注册。