Cardiovascular diseases (CVDs) are among the leading causes of mortality and morbidity worldwide. There are many contrasting ideas on the effectiveness of influenza vaccination on CVDs. This study aimed to investigate the association between influenza vaccination and the risk of CVDs. We systematically searched all PubMed/Medline, EMBASE, and the Cochrane library entries up to November 2019 for studies of influenza vs. the CVDs outcomes. We conducted a random-effects meta‐analysis using the inverse variance method for pooled risk ratios (RR) or odds ratios (OR) and evaluated statistical heterogeneity using the I² statistic. We identified 17 studies (6 randomized controlled trial [RCT], 5 cohorts, and 6 case–control) with a total of 180,043 cases and 276,898 control participants. The pooled RR of developing CVDs after influenza vaccination in RCT studies was 0.55 (95% CI 0.41–0.73), which was significant (P-value = 0.00). The pooled OR of decreasing CVDs after influenza vaccination in cohort studies was 0.89 (95% CI 0.77–1.04). The pooled OR of developing CVDs after influenza vaccination by pooling case–control studies was 0.70 (95% CI 0.57–0.86, (P-value = 0.00). All of these studies suggest decreased risks of CVDs with influenza vaccination. The current study does support the protective role of influenza vaccination on CVDs events. Health authorities may develop evidence-based preventive strategies to offer influenza vaccination in patients with CVDs.

心血管疾病（CVD）是全世界死亡率和发病率的主要原因。关于在CVD上进行流感疫苗接种的有效性有许多不同的想法。这项研究旨在调查流感疫苗接种与CVD风险之间的关联。我们系统搜索了截至2019年11月的所有PubMed / Medline，EMBASE和Cochrane库条目，以研究流感与CVD结局的关系。我们使用逆方差方法对风险总比（RR）或优势比（OR）进行了随机效应荟萃分析，并使用I ²评估了统计异质性统计。我们确定了17项研究（6项随机对照试验[RCT]，5项队列研究和6例病例对照），共计180,043例病例和276,898名对照参与者。在RCT研究中，接种流感疫苗后发展中的CVD的合并RR为0.55（95％CI 0.41-0.73），这是显着的（P值= 0.00）。队列研究中，接种流感疫苗后减少的CVD的合并OR为0.89（95％CI 0.77-1.04）。病例对照研究汇总了流感疫苗接种后发展中的CVD的合并OR为0.70（95％CI 0.57–0.86，（P值= 0.00）。所有这些研究表明，接种流感疫苗可降低CVD的风险。支持流感疫苗接种对CVD的保护作用卫生当局可能制定基于证据的预防策略，为CVD患者提供流感疫苗接种。