The SARS‐CoV‐2 pandemic has led to hundreds of thousands of deaths and billions of dollars in economic damage. The immune response elicited from this virus is poorly understood. An alarming number of cases have arisen where COVID‐19 patients develop complications on top of the symptoms already associated with SARS, such as thrombosis, injuries of vascular system, kidney, and liver, as well as Kawasaki disease. In this review, a bioinformatics approach was used to elucidate the immune response triggered by SARS‐CoV‐2 infection in primary human lung epithelial and transformed human lung alveolar. Additionally, examined the potential mechanism behind several complications that have been associated with COVID‐19 and determined that a specific cytokine storm is leading to excessive neutrophil recruitment. These neutrophils are directly leading to thrombosis, organ damage, and complement activation via neutrophil extracellular trap release.

中文翻译：

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确定由 SARS-CoV2 诱导的关键信号通路是 COVID-19 患者血栓形成和血管损伤的基础

SARS-CoV-2 大流行已导致数十万人死亡和数十亿美元的经济损失。人们对这种病毒引起的免疫反应知之甚少。已经出现了数量惊人的病例，其中 COVID-19 患者在已经与 SARS 相关的症状之上出现并发症，例如血栓形成、血管系统、肾脏和肝脏损伤以及川崎病。在这篇综述中，使用生物信息学方法阐明了 SARS-CoV-2 感染在原代人肺上皮细胞和转化的人肺泡中引发的免疫反应。此外，检查了与 COVID-19 相关的几种并发症背后的潜在机制，并确定特定的细胞因子风暴导致中性粒细胞过度募集。