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A Versatile Flexible Polymer Actuator System for Pumps, Valves, and Injectors Enabling Fully Disposable Active Microfluidics
Advanced Materials Technologies ( IF 6.8 ) Pub Date : 2020-11-26 , DOI: 10.1002/admt.202000769
Yong Zhong 1 , Daniel Filippini 1 , Edwin W. H. Jager 1
Affiliation  

To control and manipulate fluids in lab‐on‐a‐chip (LOC) devices, active components such as pumps, valves, and injectors are necessary. However, such components are often complex and expensive to fabricate, limiting integration in disposable LOCs. A new type of flexible, all‐polymer diaphragm actuator system, called Double Diaphragm Active Polymer Actuator (DDAPA), is presented as a single modular unit that can be repurposed to diverse active microfluidic components. To demonstrate the versatility of the DDAPA concept, the DDAPA devices are investigated in three different configurations: as a single operation microinjector, as a flow regulating element, and as a pump in a hybrid configuration with unibody‐LOC unidirectional systems. The working principle, fabrication process, and the three examples of microfluidic components are presented. The trilayer diaphragm actuator is realized using the conductive polymer poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate as the actuating material and thiol‐acrylate‐based ionogels as solid‐state electrolyte and base material. The three demonstrators show the feasibility of using the DDAPA module to inject liquids, regulate flow, and unidirectionally pump fluids up to 112 µL min−1 when coupled with a 3D printed unibody check valve. Hence, the presented concept with a simple mechanism and easy manufacturability, broadens the choice of disposable actuators compatible with fully disposable autonomous LOC solutions.

中文翻译:

适用于泵,阀和注射器的多功能柔性聚合物执行器系统,可实现完全一次性的活性微流体

为了控制和操作芯片实验室(LOC)设备中的流体,必须使用诸如泵,阀和进样器之类的有源组件。但是,这样的组件通常复杂且制造昂贵,从而限制了一次性LOC的集成。提出了一种新型的灵活的全聚合物膜片执行器系统,称为双膜片活性聚合物执行器(DDAPA),它是一个模块化的单元,可以重新用于多种活性微流体组件。为了证明DDAPA概念的多功能性,对DDAPA设备进行了三种不同配置的研究:作为单操作微型注射器,作为流量调节元件,以及作为具有一体式LOC单向系统的混合配置的泵。介绍了工作原理,制造工艺和微流控元件的三个实例。三层隔膜执行器是通过使用导电聚合物聚(3,4-乙撑二氧噻吩)聚苯乙烯磺酸盐作为驱动材料和基于硫醇丙烯酸酯的离子凝胶作为固态电解质和基础材料来实现的。这三个演示者展示了使用DDAPA模块来注入液体,调节流量以及单向泵送最小为112 µL的流体的可行性。-1与3D打印的一体式止回阀结合时。因此,所提出的概念具有简单的机构和容易的可制造性,拓宽了与完全一次性自主LOC解决方案兼容的一次性致动器的选择。
更新日期:2021-01-05
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