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L-theanine suppresses the metastasis of prostate cancer by downregulating MMP9 and Snail
The Journal of Nutritional Biochemistry ( IF 5.6 ) Pub Date : 2020-11-26 , DOI: 10.1016/j.jnutbio.2020.108556
Xirui Fan 1 , Jinyi Zhou 1 , Xiaowen Bi 1 , Juanjuan Liang 1 , Shuai Lu 1 , Xintong Yan 1 , Lan Luo 2 , Zhimin Yin 1
Affiliation  

Prostate cancer (PCa) is a very prevalent male-specific malignancy; most PCa patients eventually die as a result of metastasis. L-theanine (C7H14N2O3), a nonprotein amino acid derivative from green tea leaves, has been demonstrated to act as an anticarcinogen through proapoptotic and antiproliferative effects. However, the antimetastatic effect of L-theanine in tumor cells and its underlying mechanism are still unclear. Here, we found that L-theanine could suppress invasion, migration, and increase cell-cell adhesion of prostate cancer cells in vitro and in vivo. We also found that L-theanine could inhibit the epithelial-mesenchymal transition process in PCa. Our study revealed that L-theanine could downregulate MMP9, N-cadherin, Vimentin, Snail, and upregulate E-cadherin. Furthermore, L-theanine suppressed the transcription of MMP9 and Snail by significantly inhibiting the ERK/NF-κB signaling pathway and the binding activity of p65 to the promoter regions of MMP9 and Snail. All of these findings suggest that L-theanine has therapeutic potential for metastatic PCa and may be considered a promising candidate for antimetastatic therapy of prostate cancer.



中文翻译:

L-茶氨酸通过下调 MMP9 和 Snail 抑制前列腺癌的转移

前列腺癌 (PCa) 是一种非常普遍的男性特异性恶性肿瘤。大多数 PCa 患者最终会因转移而死亡。L-茶氨酸 (C7H14N2O3) 是一种来自绿茶叶的非蛋白质氨基酸衍生物,已被证明可通过促凋亡和抗增殖作用发挥抗癌作用。然而,L-茶氨酸在肿瘤细胞中的抗转移作用及其潜在机制尚不清楚。在这里,我们发现 L-茶氨酸可以在体外体内抑制前列腺癌细胞的侵袭、迁移和增加细胞间粘附. 我们还发现 L-茶氨酸可以抑制 PCa 中的上皮-间质转化过程。我们的研究表明,L-茶氨酸可以下调 MMP9、N-钙粘蛋白、波形蛋白、蜗牛,并上调 E-钙粘蛋白。此外,L-茶氨酸通过显着抑制 ERK/NF-κB 信号通路和 p65 与 MMP9 和 Snail 启动子区域的结合活性来抑制 MMP9 和 Snail 的转录。所有这些发现表明 L-茶氨酸对转移性 PCa 具有治疗潜力,可能被认为是前列腺癌抗转移治疗的有希望的候选者。

更新日期:2020-12-14
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