A wide range of insults can trigger acute injury in the lungs, which eventually may lead to respiratory failure and death of patients. Current treatment relies mainly on supportive measures and mechanical ventilation. Even so, survivors frequently develop important sequels that compromise quality of life. In the search for new approaches to prevent and treat acute lung injury, many investigations have focused on molecular and cellular pathways which could exert a pathogenic role in this disease. Herein, we review recent findings in the literature suggesting that cellular senescence could be involved in lung injury and discuss the potential use of senotherapies to prevent disease progression.

范围广泛的损伤可引发肺部急性损伤，最终可能导致患者呼吸衰竭和死亡。目前的治疗主要依靠支持措施和机械通气。即便如此，幸存者经常会发展出影响生活质量的重要续集。在寻找预防和治疗急性肺损伤的新方法的过程中，许多研究都集中在可能在这种疾病中发挥致病作用的分子和细胞通路上。在此，我们回顾了最近文献中的发现，表明细胞衰老可能与肺损伤有关，并讨论了 senotherapies 预防疾病进展的潜在用途。