当前位置: X-MOL 学术Biomater. Adv. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A comparison of the degradation behaviour of 3D printed PDLGA scaffolds incorporating bioglass or biosilica
Biomaterials Advances ( IF 7.9 ) Pub Date : 2020-11-27 , DOI: 10.1016/j.msec.2020.111755
R. Han , F. Buchanan , L. Ford , M. Julius , P.J. Walsh

Silica incorporation into biomaterials, such as Bioglass and Si-substituted calcium phosphate ceramics has received significant attention in bone tissue engineering over the last few decades. This study aims to explore the dissolution behaviour of natural biosilica isolated from a freshwater diatom, Cyclotella meneghiniana, that has been incorporated into 3D printed poly (DL-lactide -co – glycolide) (PDLGA) scaffolds using extrusion and additive manufacturing. In the study, two different dry weight percentage (1 wt% & 5 wt%) of diatom-silica were incorporated into PDLGA scaffolds that were then degraded in phosphate buffered saline (PBS) cell free media. In addition, pure PDLGA scaffolds and 5 wt% Bioglass scaffolds were used as control groups. The degradation study was performed over 26-weeks. The release rate of Si4+ ions from diatom-PDLGA scaffolds was found to increase exponentially with respect to time. The compressive strength of scaffolds was also measured with the Diatom–PDLGA scaffolds found to maintain their strength for longer than either pure PDLGA scaffolds or 5 wt% Bioglass scaffolds. 13C NMR data showed that diatom biosilica containing scaffolds had less degradation than pure or bioglass-containing scaffolds at comparable time-points. Overall, the Diatom-PDLGA scaffolds were found to have more desirable physiochemical properties for bone repair compared to Bioglass.



中文翻译:

包含生物玻璃或生物二氧化硅的3D打印PDLGA支架降解行为的比较

在过去的几十年中,将二氧化硅掺入生物材料(例如Bioglass和Si取代的磷酸钙陶瓷)中已引起骨组织工程的广泛关注。这项研究旨在探讨从淡水硅藻Cyclotella meneghiniana,该产品已通过挤出和增材制造技术被集成到3D打印的聚(DL-丙交酯-乙交酯)(PDLGA)支架中。在这项研究中,将两种不同干重百分比(1 wt。%和5 wt。%)的硅藻土掺入PDLGA支架中,然后在无磷酸盐缓冲盐水(PBS)的无细胞培养基中降解。另外,将纯的PDLGA支架和5重量%的Bioglass支架用作对照组。降解研究进行了26周。发现硅藻土-PDLGA支架中Si 4+离子的释放速率随时间呈指数增长。还用硅藻土-PDLGA支架测量了支架的抗压强度,发现该支架的强度比纯PDLGA支架或5 wt%的Bioglass支架更长。131 H NMR数据表明,在可比较的时间点,含硅藻生物二氧化硅的支架比纯的或含生物玻璃的支架具有更少的降解。总体而言,与Bioglass相比,发现Diatom-PDLGA支架具有更理想的骨修复理化特性。

更新日期:2020-12-05
down
wechat
bug