Four novel heterocyclic1,3,4-oxadiazole, 1,2,4-triazole derivatives, namely : 5-[1-amino-3-(methylsulfanyl)propyl]-1,3,4-oxadiazole-2(3H)-thione (4), 4-amino-5-[1-amino-3-(methylsulfanyl)propyl]-4H-1,2,4-triazole-3-thiol (5), 1-amino-3-[1-amino-3-(methylsulfanyl)propyl]-1H-1,2,4-triazole-5-thiol (7), and 5-[1-amino-3-(methylsulfanyl)propyl]-1H-1,2,4-triazole-3-thiol (9) have been synthesized from l-methionine and characterized by different spectroscopic techniques (FT-IR, UV-Vis, ¹H-NMR, ¹³C-NMR and MS). Complex formation with Hg⁺⁺ and Fe⁺⁺⁺ ions were formed from the four heterocyclic 4, 5, 7 and 9.The antimicrobial activities for synthetic intermediates and final four products were assisted using paper disk diffusion method against Gram-negative bacteria: Escherichia coli, Pseudomonas aeroginosae and Gram-positive bacteria: Staphylococus aureus 25923, Staphylococus aureus 43300 and showed variant activity against some of the microorganisms tested.

四个新的杂环1,3,4-恶二唑，1,2,4-三唑衍生物，即：5- [1-氨基-3-（甲基硫烷基）丙基] -1,3,4-恶二唑-2（3 H）-硫酮（4），4-氨基-5- [1-氨基-3-（甲基硫烷基）丙基] -4 H -1,2,4-三唑-3-硫醇（5），1-氨基-3- [1 -氨基-3-（甲基硫烷基）丙基] -1 H -1,2,4-三唑-5-硫醇（7）和5- [1-氨基-3-（甲基硫烷基）丙基] -1 H -1，由1-甲硫氨酸合成了2，4-三唑-3-硫醇（9），并通过不同的光谱技术（FT-IR，UV-Vis，¹ H-NMR，¹³ C-NMR和MS）进行了表征。与Hg ⁺⁺形成复合物和Fe ⁺⁺⁺离子从四个杂环形成4，5，7和9 .The抗微生物合成中间体和最终四种产品活动纸张使用纸片法对革兰氏阴性细菌提供了协助：大肠杆菌，铜绿aeroginosae和革兰氏阳性细菌：金黄色葡萄球菌25923，金黄色葡萄球菌43300，对某些测试微生物表现出不同的活性。