In this contribution, a metal- and base-free protocol has been developed for the synthesis of phosphorochalcogenoates (Se and Te) by using DMSO as solvent at 50 ˚C. A variety of phosphorochalcogenoates were prepared from diorganyl dichalcogenides and H-phosphonates, leading to the formation of a Chal-P(O) bond, in a rapid procedure with good to excellent yields. A full structural elucidation of products was accessed by 1D and 2D NMR, IR, CGMS, and HRMS analyses, and a stability evaluation of the phosphorochalcogenoates was performed for an effective operational description of this simple and feasible method. Typical ⁷⁷Se{¹H} (δ_Se = 866.0 ppm), ¹²⁵Te{¹H} (δ_Te = 422.0 ppm) and ³¹P{¹H} (δ_P = -1.0, -13.0 and -15.0 ppm) NMR chemical shifts were imperative to confirm the byproducts, in which this stability study was also important to select some products for pharmacological screening. The phosphorochalcogenoates were screened in vitro and ex vivo tests for the antioxidant potential and free radical scavenging activity, as well as to investigation toxicity in mice through of the plasma levels of markers of renal and hepatic damage. The pharmacological screening of phosphorochalcogenoates indicated that compounds have antioxidant propriety in different assays and not changes plasma levels of markers of renal and hepatic damage, with excision of 3g compound that increased plasma creatinine levels and decreased plasma urea levels when compared to control group in the blood mice. Thus, these compounds can be promising synthetic antioxidants that provide protection against oxidative diseases.

在这一贡献中，已开发出一种无金属和碱的方案，用于通过在50°C下使用DMSO作为溶剂来合成磷碳氢酸盐（Se和Te）。由二有机基二卤代膦酸酯和H-膦酸酯制备了多种磷代碳氢酸酯，导致了Chal-P（O）键的形成，反应速度快，收率好至极佳。通过1D和2D NMR，IR，CGMS和HRMS分析获得了产品的完整结构说明，并进行了磷藻酸酯的稳定性评估以有效地描述这种简单可行的方法。典型⁷⁷硒{ ^1个H}（δ_硒= 866.0 ppm）设为¹²⁵碲{ ^1个H}（δ_TE = 422.0 PPM）和³¹ p { ^1个H}（δ _P = -1.0，-13.0 -15.0和PPM）NMR化学位移均必须确认的副产物，其中该稳定性研究也很重要选择一些产品的药理学筛选。在体外和离体中筛选了磷酸胆碱酯进行抗氧化剂潜力和自由基清除活性测试，并通过血浆肾脏和肝损伤标志物的水平调查小鼠的毒性。药代磷酸酯的药理学筛选表明，该化合物在不同的测定方法中具有抗氧化剂的特性，并且不会改变肾脏和肝损伤标志物的血浆水平，与血液中的对照组相比，切除3g化合物会增加血浆肌酐水平并降低血浆尿素水平。老鼠。因此，这些化合物可能是有前途的合成抗氧化剂，提供抗氧化性疾病的保护。