Abstract Background Psychiatric disorders are one of the largest and fastest growing categories of the global disease burden. However, limited effort has been made to further elucidate the associations between the socioeconomic factors and psychiatric disorders from a genetic perspective. Methods We randomly divided 501, 882 participants in the UK Biobank cohort with socioeconomic Townsend deprivation index (TDI) data into two cohorts: the discovery cohort and the replication cohort. For the two cohorts, we first conducted regression analyses to evaluate the associations between the TDI and common psychiatric disorders or traits, including anxiety, bipolar disorder (BD), self-harm, and depression (based on self-reported depression and PHQ scores). We then performed a genome-wide gene-environment interaction study (GWGEIS) using PLINK2.0 with the TDI as an environmental factor to explore the interaction effects. Results: In the discovery cohort, significant associations were observed between TDI and psychiatric disorders with P value Conclusions Our findings suggested the relevance of TDI with psychiatric disorders. GWGEIS identified several candidate genes interacting with TDI, providing novel clues for understanding the biological mechanism of the associations between TDI and psychiatric disorders.

中文翻译：

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社会经济剥夺指数与精神疾病有关：英国生物银行队列中的观察性和全基因组基因-环境相互作用分析

摘要背景精神疾病是全球疾病负担中最大和增长最快的类别之一。然而，从遗传角度进一步阐明社会经济因素与精神疾病之间的关联的努力有限。方法 我们将英国生物银行队列中具有社会经济汤森剥夺指数 (TDI) 数据的 501、882 名参与者随机分为两个队列：发现队列和复制队列。对于这两个队列，我们​​首先进行回归分析以评估 TDI 与常见精神疾病或特征之间的关联，包括焦虑、双相情感障碍 (BD)、自残和抑郁（基于自我报告的抑郁和 PHQ 评分） . 然后，我们使用 PLINK2 进行了全基因组基因-环境相互作用研究 (GWGEIS)。0 以 TDI 作为环境因子来探索交互作用。结果：在发现队列中，观察到 TDI 与具有 P 值的精神疾病之间的显着关联 结论 我们的研究结果表明 TDI 与精神疾病的相关性。GWGEIS 确定了几个与 TDI 相互作用的候选基因，为了解 TDI 与精神疾病之间关联的生物学机制提供了新的线索。