Mechanosensitive ion channels are responsible for touch sensation and proprioception in higher level organisms such as humans and recovery after osmotic stress in bacteria. Bacterial mechanosensitive channels are homologous to either the mechanosensitive channel of large conductance (MscL) or the mechanosensitive channel of small conductance (MscS). In the E. coli genome there are seven unique mechanosensitive channels, a single MscL homologue, and six MscS homologues. The six MscS homologues are members of the diverse MscS superfamily of ion channels, and these channels show variation on both the N and C termini when compared to E. coli MscS. In bacterial strains with phenotypic analysis of the endogenous mechanosensors, the quantity of MscS superfamily members in the genome range from 2 to 6 and all of the strains contain a copy of MscL. Here, we show an in-depth analysis of over 150 diverse bacterial genomes, encompassing nine phyla, to determine the number of genomes that contain an MscL homologue and the average number of MscS superfamily members per genome. We determined that the average genome contains 4 ± 3 MscS homologues and 67% of bacterial genomes encode for a MscL homologue.

机械敏感离子通道负责人类等高级生物的触觉和本体感觉以及细菌渗透压力后的恢复。细菌机械敏感通道与大电导机械敏感通道 (MscL) 或小电导机械敏感通道 (MscS) 同源。在大肠杆菌基因组中，有七个独特的机械敏感通道、一个 MscL 同源物和六个 MscS 同源物。六个 MscS 同源物是不同的 MscS 离子通道超家族的成员，与大肠杆菌相比，这些通道在 N 和 C 末端都显示出变化理学硕士。在对内源性机械传感器进行表型分析的细菌菌株中，基因组中 MscS 超家族成员的数量范围为 2 到 6 个，并且所有菌株都包含一个 MscL 副本。在这里，我们展示了对 150 多个不同细菌基因组（包括 9 个门）的深入分析，以确定包含 MscL 同源物的基因组数量和每个基因组的 MscS 超家族成员的平均数量。我们确定平均基因组包含 4 ± 3 个 MscS 同源物，67% 的细菌基因组编码 MscL 同源物。