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rRNA Methylation and Antibiotic Resistance
Biochemistry (Moscow) ( IF 2.8 ) Pub Date : 2020-11-01 , DOI: 10.1134/s000629792011005x
I A Osterman 1, 2 , O A Dontsova 1, 2, 3 , P V Sergiev 1, 2, 4
Affiliation  

Methylation of nucleotides in rRNA is one of the basic mechanisms of bacterial resistance to protein synthesis inhibitors. The genes for corresponding methyltransferases have been found in producer strains and clinical isolates of pathogenic bacteria. In some cases, rRNA methylation by housekeeping enzymes is, on the contrary, required for the action of antibiotics. The effects of rRNA modifications associated with antibiotic efficacy may be cooperative or mutually exclusive. Evolutionary relationships between the systems of rRNA modification by housekeeping enzymes and antibiotic resistance-related methyltransferases are of particular interest. In this review, we discuss the above topics in detail.

中文翻译:

rRNA 甲基化和抗生素耐药性

rRNA 中核苷酸的甲基化是细菌对蛋白质合成抑制剂产生抗性的基本机制之一。已在病原菌的生产菌株和临床分离株中发现了相应甲基转移酶的基因。在某些情况下,管家酶的 rRNA 甲基化是抗生素作用所必需的。与抗生素功效相关的 rRNA 修饰的影响可能是合作的或相互排斥的。管家酶和抗生素抗性相关甲基转移酶的 rRNA 修饰系统之间的进化关系特别令人感兴趣。在这篇评论中,我们详细讨论了上述主题。
更新日期:2020-11-01
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