In recent years, considerable attention has been devoted to the exploration of novel synthetic methods for fluoro-lactams due to their significant biological and pharmaceutical activities. This review summarizes recently established strategies for synthesizing fluorine-substituted lactams, including fluoro-β-lactams, fluoro-γ-lactams, and fluoro-δ-lactams. Additionally, the reaction scopes, limitations, and mechanisms are discussed.

中文翻译：

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含氟内酰胺单元的化合物的合成方法

近年来，由于氟内酰胺具有显着的生物和药学活性，人们对探索新的氟内酰胺合成方法给予了相当大的关注。这篇综述总结了最近建立的合成氟取代内酰胺的策略，包括氟-β-内酰胺、氟-γ-内酰胺和氟-δ-内酰胺。此外，还讨论了反应范围、局限性和机理。