There is inconclusive evidence on the association between ambient air pollution and pulmonary tuberculosis-related hospital admission and mortality. This review aims to assess if and to what extent, selected air pollutants are associated to pulmonary tuberculosis (PTB) incidence, hospital admissions and mortality. This will be a systematic review and meta-analysis of studies published in English between January 1st, 1946 and October 31st, 2020, quantitatively assessing the association between air pollutants and PTB incidence, hospital admissions and mortality. A comprehensive search strategy will be used to search the databases: Medline, Embase, Scopus and The Cochrane Library. Retrieved studies will be screened based on the set eligibility criteria and data will be extracted from eligible studies. Extracted data will be analysed on STATA version 14.0 software. Studies included will be assessed for their quality using the respective Study Quality Assessment Tools of the National Health Institute. The quality of the evidence on the study outcomes will be graded using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. The risk of bias will be assessed using Cochrane’s Risk of Bias In Non-randomized Studies-of Interventions (ROBINS-I) tool. Study characteristics, socio-demographic and clinical characteristics across eligible studies will be summarised and presented. Pooled estimates of the measures of association between air pollutants and PTB incidence, hospital admission and mortality will be obtained through random-effect meta-analyses models and the respective I2 test statistics will be reported. Meta-regression analyses will be done in case of significant between-study heterogeneity.

中文翻译：

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周围空气污染与肺结核之间的关联：系统评价方案

关于周围空气污染与肺结核相关的住院率和死亡率之间的关系，尚无定论。这篇综述旨在评估选定的空气污染物是否以及在多大程度上与肺结核（PTB）的发病率，住院人数和死亡率有关。这将是对1946年1月1日至2020年10月31日之间以英语发表的研究的系统回顾和荟萃分析，以定量评估空气污染物与PTB发病率，住院人数和死亡率之间的关系。全面的搜索策略将用于搜索数据库：Medline，Embase，Scopus和The Cochrane库。将根据设定的资格标准筛选检索到的研究，并从符合条件的研究中提取数据。提取的数据将在STATA 14.0版软件上进行分析。将使用国家卫生研究院的研究质量评估工具来评估所纳入研究的质量。研究结果的证据质量将使用“建议评估，发展和评估等级”（GRADE）方法进行分级。将使用Cochrane在非随机干预研究中的偏倚风险（ROBINS-I）工具评估偏倚风险。将总结并介绍符合条件的研究的研究特征，社会人口统计学和临床​​特征。将通过随机效应荟萃分析模型获得空气污染物与PTB发病率，入院率和死亡率之间的关联度量的汇总估计值，并将报告各自的I2测试统计数据。