This study aimed to quantitatively summarize the evidence for VDR BsmI gene polymorphism and osteoporosis risk in postmenopausal women. The PubMed, EMBASE, Weipu, CNKI, and Wanfang databases were searched for eligible studies. Case-control studies containing available genotype frequencies of B/b were chosen, and odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. 4485 osteoporosis and 5490 controls were identified in our meta-analysis. In the stratified analysis, a significant association was observed between VDR BsmI gene polymorphism and osteoporosis susceptibility in Caucasians (additive model: OR = 0.809, 95% CI 0.678~0.965, p = 0.019; recessive model: OR = 0.736, 95% CI 0.568~0.955, p = 0.021; and co-dominant model: bb vs. BB OR = 0.701, 95% CI 0.511~0.962 p = 0.028), and we failed to find any significant relationship in Asians. The present meta-analysis suggests that VDR BsmI genotype is associated with increased risk of postmenopausal osteoporosis in Caucasians but not in Asians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR BsmI polymorphism and osteoporosis in postmenopausal women.

中文翻译：

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绝经后女性维生素 D 受体 Bsm I 多态性和骨质疏松风险：42 项研究的荟萃分析

本研究旨在定量总结 VDR BsmI 基因多态性和绝经后女性骨质疏松风险的证据。检索了 PubMed、EMBASE、Weipu、CNKI 和万方数据库中符合条件的研究。选择包含 B/b 可用基因型频率的病例对照研究，并使用具有 95% 置信区间 (CI) 的比值比 (OR) 来评估这种关联的强度。我们的荟萃分析中确定了 4485 名骨质疏松症患者和 5490 名对照者。分层分析中，白种人中VDR BsmI基因多态性与骨质疏松易感性之间存在显着相关性（加性模型：OR = 0.809，95% CI 0.678~0.965，p = 0.019；隐性模型：OR = 0.736，95% CI 0.568 ~0.955，p = 0.021；以及共同主导模型：bb 与 BB OR = 0.701，95% CI 0.511~0.962 p = 0.028），我们未能在亚洲人中发现任何显着关系。目前的荟萃分析表明，VDR BsmI 基因型与白种人绝经后骨质疏松症风险增加相关，但与亚洲人无关。为了得出全面、真实的结论，需要对全球范围内更多的参与者进行进一步的前瞻性研究，以检查 VDR BsmI 多态性与绝经后妇女骨质疏松症之间的关联。