We herein communicate a formal dehydrogenative coupling of carbonyls with polyfluoroarenes enabled by Cu catalysis. Silyl enol ethers initially prepared from carbonyls are postulated to undergo the copper-mediated oxidative dehydrogenative coupling with polyfluoroarenes via a radical pathway. Including cyclic and linear ketones, aldehydes, and esters, a broad range of β-aryl carbonyl products were efficiently obtained in high regio- and stereoselectivity with excellent functional group tolerance.

中文翻译：

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铜催化羰基化合物与多氟芳烃的正式脱氢偶联导致 β-C-H 芳基化

我们在此交流了通过 Cu 催化实现的羰基与多氟芳烃的正式脱氢偶联。假设最初由羰基化合物制备的甲硅烷基烯醇醚通过自由基途径与多氟芳烃进行铜介导的氧化脱氢偶联。包括环状和线性酮、醛和酯在内，以高区域和立体选择性和优异的官能团耐受性有效地获得了广泛的 β-芳基羰基产物。