Few studies have reported the function of LYNX1 in ovarian cancer. We retrieved LYNX1 gene expression data and clinical information of 376 patients with ovarian cancer from The Cancer Genome Atlas (TCGA) project website. Wilcoxon signed-rank test and logistic regression were used to analyze the relationship between clinical pathologic features and LYNX1 expression. The Kaplan–Meier method was used to draw survival curves of patients, and Cox regression was used to calculate the relationship between LYNX1 expression and survival rate or the clinicopathological characteristics of the patients. Gene set enrichment analysis (GSEA) was performed, and the correlation between LYNX1 expression and cancer immune infiltrates was investigated via single sample gene set enrichment analysis (ssGSEA). High LYNX1 expression in ovarian serous cystadenocarcinoma (OVs) was associated with tumor residual disease (RD). In Kaplan–Meier survival analysis, patients with OVs who also displayed high LYNX1 expression had decreased overall survival (OS) and disease-specific survival (DSS) than those with low LYNX1 expression. Univariate analysis also supported that patients with high LYNX1 expression had lower OS than those with low LYNX1 expression. LYNX1 expression has the potential to be a prognostic molecular marker of poor survival in OVs.

中文翻译：

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LYNX1在卵巢浆液性膀胱腺样癌中的表达增加预示不良预后。

很少有研究报道LYNX1在卵巢癌中的功能。我们从癌症基因组图谱（TCGA）项目网站检索了376例卵巢癌患者的LYNX1基因表达数据和临床信息。使用Wilcoxon符号秩检验和logistic回归分析临床病理特征与LYNX1表达之间的关系。使用Kaplan–Meier方法绘制患者的生存曲线，并使用Cox回归计算LYNX1表达与生存率或患者临床病理特征之间的关系。进行基因集富集分析（GSEA），并通过单样本基因集富集分析（ssGSEA）研究LYNX1表达与癌症免疫浸润之间的相关性。卵巢浆液性囊腺癌（OVs）中高LYNX1表达与肿瘤残留疾病（RD）相关。在Kaplan–Meier生存分析中，与LYNX1表达低的患者相比，OVS患者也显示出高的LYNX1表达，其总生存（OS）和疾病特异性生存（DSS）降低。单变量分析还支持高LYNX1表达的患者的OS低于低LYNX1表达的患者。LYNX1表达有可能成为OVs不良生存的预后分子标志物。单变量分析还支持高LYNX1表达的患者的OS低于低LYNX1表达的患者。LYNX1表达有可能成为OVs不良生存的预后分子标志物。单变量分析还支持高LYNX1表达的患者的OS低于低LYNX1表达的患者。LYNX1表达有可能成为OVs不良生存的预后分子标志物。