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Neural circuit mechanisms of sexual receptivity in Drosophila females
Nature ( IF 64.8 ) Pub Date : 2020-11-25 , DOI: 10.1038/s41586-020-2972-7
Kaiyu Wang , Fei Wang , Nora Forknall , Tansy Yang , Christopher Patrick , Ruchi Parekh , Barry J. Dickson

Choosing a mate is one of the most consequential decisions a female will make during her lifetime. A female fly signals her willingness to mate by opening her vaginal plates, allowing a courting male to copulate 1 , 2 . Vaginal plate opening (VPO) occurs in response to the male courtship song and is dependent on the mating status of the female. How these exteroceptive (song) and interoceptive (mating status) inputs are integrated to regulate VPO remains unknown. Here we characterize the neural circuitry that implements mating decisions in the brain of female Drosophila melanogaster . We show that VPO is controlled by a pair of female-specific descending neurons (vpoDNs). The vpoDNs receive excitatory input from auditory neurons (vpoENs), which are tuned to specific features of the D. melanogaster song, and from pC1 neurons, which encode the mating status of the female 3 , 4 . The song responses of vpoDNs, but not vpoENs, are attenuated upon mating, accounting for the reduced receptivity of mated females. This modulation is mediated by pC1 neurons. The vpoDNs thus directly integrate the external and internal signals that control the mating decisions of Drosophila females. In Drosophila melanogaster , female mating decisions are governed by female-specific descending neurons that integrate input from auditory neurons that respond to features of the song of a conspecific male and central neurons that encode the mating status of the female.

中文翻译:

果蝇雌性性接受能力的神经回路机制

选择配偶是女性一生中做出的最重要的决定之一。一只雌性苍蝇通过打开她的阴道板来表示她愿意交配,让一个求爱的雄性交配 1 , 2 。阴道板打开 (VPO) 发生在对雄性求爱歌曲的响应中,并且取决于雌性的交配状态。这些外感受(歌曲)和内感受(交配状态)输入如何整合以调节 VPO 仍然未知。在这里,我们描述了在雌性黑腹果蝇大脑中执行交配决定的神经回路。我们表明 VPO 由一对女性特定的下行神经元 (vpoDN) 控制。vpoDNs 接收来自听觉神经元 (vpoENs) 的兴奋性输入,这些神经元被调整到 D. melanogaster 歌曲的特定特征,以及来自 pC1 神经元,其中编码雌性 3 、 4 的交配状态。vpoDNs 而不是 vpoENs 的歌曲反应在交配时减弱,这是交配雌性的接受能力降低的原因。这种调制是由 pC1 神经元介导的。因此,vpoDN 直接整合了控制果蝇雌性交配决定的外部和内部信号。在黑腹果蝇中,雌性交配决定由雌性特异性下降神经元控制,这些神经元整合来自听觉神经元的输入,这些神经元响应同种雄性和中枢神经元的歌曲特征,编码雌性交配状态。因此,vpoDN 直接整合了控制果蝇雌性交配决定的外部和内部信号。在黑腹果蝇中,雌性交配决定由雌性特异性下降神经元控制,这些神经元整合来自听觉神经元的输入,这些神经元响应同种雄性和中枢神经元的歌曲特征,编码雌性交配状态。因此,vpoDN 直接整合了控制果蝇雌性交配决定的外部和内部信号。在黑腹果蝇中,雌性交配决定由雌性特异性下降神经元控制,这些神经元整合来自听觉神经元的输入,这些神经元响应同种雄性和中枢神经元的歌曲特征,编码雌性交配状态。
更新日期:2020-11-25
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