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Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice
Bioengineering & Translational Medicine ( IF 7.4 ) Pub Date : 2020-11-25 , DOI: 10.1002/btm2.10202
Chaiyaporn Kuwentrai 1 , Jinming Yu 2 , Li Rong 1 , Bao-Zhong Zhang 1, 3 , Ye-Fan Hu 1, 4 , Hua-Rui Gong 1 , Ying Dou 1 , Jian Deng 1 , Jian-Dong Huang 1, 3 , Chenjie Xu 2
Affiliation  

The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike protein contains an immunogenic receptor‐binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S‐RBD vaccine using a dissolvable microneedle skin patch can induce both significant B‐cell and significant T‐cell responses against S‐RBD. Importantly, the outcomes were comparable to that of conventional bolus injection.

中文翻译:

用可溶性微针皮内递送 SARS-CoV-2 刺突蛋白受体结合域以诱导小鼠的体液和细胞反应

严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 刺突蛋白的 S1 亚基含有一个免疫原性受体结合结构域 (RBD),这是开发潜在疫苗的有希望的候选者。这项研究表明,使用可溶性微针皮肤贴片皮内递送 S-RBD 疫苗可以诱导显着的 B 细胞和显着的 T 细胞对 S-RBD 的反应。重要的是,结果与传统的快速推注相当。
更新日期:2021-01-24
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