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Linking nutrient sensing and gene expression in Plasmodium falciparum blood-stage parasites
Molecular Microbiology ( IF 3.6 ) Pub Date : 2020-11-25 , DOI: 10.1111/mmi.14652 Manish Kumar 1 , Kristen Skillman 1 , Manoj T Duraisingh 1
Molecular Microbiology ( IF 3.6 ) Pub Date : 2020-11-25 , DOI: 10.1111/mmi.14652 Manish Kumar 1 , Kristen Skillman 1 , Manoj T Duraisingh 1
Affiliation
Malaria is one of the most life-threatening infectious diseases worldwide, caused by infection of humans with parasites of the genus Plasmodium. The complex life cycle of Plasmodium parasites is shared between two hosts, with infection of multiple cell types, and the parasite needs to adapt for survival and transmission through significantly different metabolic environments. Within the blood-stage alone, parasites encounter changing levels of key nutrients, including sugars, amino acids, and lipids, due to differences in host dietary nutrition, cellular tropism, and pathogenesis. In this review, we consider the mechanisms that the most lethal of malaria parasites, Plasmodium falciparum, uses to sense nutrient levels and elicit changes in gene expression during blood-stage infections. These changes are brought about by several metabolic intermediates and their corresponding sensor proteins. Sensing of distinct nutritional signals can drive P. falciparum to alter the key blood-stage processes of proliferation, antigenic variation, and transmission.
中文翻译:
将恶性疟原虫血期寄生虫的营养感应和基因表达联系起来
疟疾是世界范围内最危及生命的传染病之一,由人类感染疟原虫属寄生虫引起。疟原虫的复杂生命周期在两个宿主之间共享,感染多种细胞类型,寄生虫需要适应生存和通过显着不同的代谢环境传播。由于宿主饮食营养、细胞嗜性和发病机制的差异,仅在血液阶段,寄生虫就会遇到关键营养素水平的变化,包括糖、氨基酸和脂质。在这篇综述中,我们考虑了最致命的疟疾寄生虫恶性疟原虫的机制,用于在血液阶段感染期间感知营养水平并引发基因表达的变化。这些变化是由几种代谢中间体及其相应的传感器蛋白引起的。感知不同的营养信号可以驱动恶性疟原虫改变增殖、抗原变异和传播的关键血液阶段过程。
更新日期:2020-11-25
中文翻译:
将恶性疟原虫血期寄生虫的营养感应和基因表达联系起来
疟疾是世界范围内最危及生命的传染病之一,由人类感染疟原虫属寄生虫引起。疟原虫的复杂生命周期在两个宿主之间共享,感染多种细胞类型,寄生虫需要适应生存和通过显着不同的代谢环境传播。由于宿主饮食营养、细胞嗜性和发病机制的差异,仅在血液阶段,寄生虫就会遇到关键营养素水平的变化,包括糖、氨基酸和脂质。在这篇综述中,我们考虑了最致命的疟疾寄生虫恶性疟原虫的机制,用于在血液阶段感染期间感知营养水平并引发基因表达的变化。这些变化是由几种代谢中间体及其相应的传感器蛋白引起的。感知不同的营养信号可以驱动恶性疟原虫改变增殖、抗原变异和传播的关键血液阶段过程。