In several experimental conditions, neuronal excitation at the perirhinal cortex (PC) does not propagate to the entorhinal cortex (EC) due to a “wall” of inhibition, which may help to create functional coupling and un‐coupling of the PC and EC in the medial temporal lobe. However, little is known regarding the coupling control process. Herein, we propose that the deep layer of area 35 in the PC plays a pivotal role in opening the gate for coupling, thus allowing the activity in the PC to propagate to the EC. Using voltage‐sensitive dye imaging for the brain slices of rodents, we show that a slowly inactivating potassium conductance in this area is essential to induce excitation overtaking the inhibitory control. This coupling between the distinct neural circuits persists for at least 1 h. We elucidate further implications of this network‐level plastic behavior and its mechanism.

中文翻译：

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周围皮层区域 35 控制周围和内嗅 - 海马电路之间的功能联系

在几个实验条件下，由于抑制的“墙”，周围皮层 (PC) 的神经元兴奋不会传播到内嗅皮层 (EC)，这可能有助于产生 PC 和 EC 的功能耦合和解偶联。内侧颞叶。然而，关于耦合控制过程知之甚少。在此，我们提出 PC 中区域 35 的深层在打开耦合门方面起着关键作用，从而允许 PC 中的活动传播到 EC。对啮齿动物的脑切片使用电压敏感染料成像，我们表明该区域缓慢失活的钾电导对于诱导超过抑制控制的兴奋是必不可少的。不同神经回路之间的这种耦合持续至少 1 小时。