The application of modern nanomedicines to enhance wound healing is growing due to their simplicity for topical organization and fast flexibility with molecules that can boost and reinforce the process of healing even in patients with diabetes. The point of the present investigation was to synthesize effective Pterocarpus marsupium heartwood extract/chitosan nanoparticles (PM-CNPs) loaded hydrogel (PM-CNPsH) and evaluate its drug release efficiency, in-vitro anti-microbial activity and wound healing action in streptozotocin administered diabetic rat models. The prepared PM-CNPs further utilized for the preparation of various carbopol hydrogel formulations. Hence, prepared hydrogels are characterized for pH, morphology, consistency, and spreadability; thus, PM-CNPsH-1 is found to be the optimized formulation. In-vivo rats treated with PM-CNPsH-1 displayed significantly much quicker healing of wounds in diabetic and non-diabetic rats. The histological examination revealed re-epithelization and growth of granular tissue and an improvement in collagen deposition. These results indicate the effectiveness of optimized nanocomposites as a potential treatment for curing diabetic wounds.

现代纳米药物在促进伤口愈合方面的应用正在增长，这是因为它们对局部组织的简单性以及具有即使在糖尿病患者中也可以促进和加强愈合过程的分子的快速柔韧性。本研究的重点是合成有效的负载紫檀心材提取物/壳聚糖纳米颗粒（PM-CNPs）的水凝胶（PM-CNPsH）并评估其体外药物释放效率链脲佐菌素治疗的糖尿病大鼠模型中的抗微生物活性和伤口愈合作用。所制备的PM-CNP进一步用于制备各种卡波姆水凝胶制剂。因此，制备的水凝胶具有pH值，形态，稠度和铺展性的特点。因此，发现PM-CNPsH-1是最佳配方。用PM-CNPsH-1治疗的体内大鼠在糖尿病和非糖尿病大鼠中显示出明显更快的伤口愈合。组织学检查显示颗粒组织重新上皮生长，胶原沉积改善。这些结果表明优化的纳米复合材料作为治疗糖尿病伤口的潜在疗法的有效性。