The goal of the research was to show the limits within which Tm³⁺ can be used as a linear response probe in lipid membrane. Temperature dependence of lanthanide-induced chemical shifts (LISs) were studied using the example of DOPC phospholipid by means of NMR spectroscopy. It was demonstrated that these dependences have thermal feature, which could be connected with the changes of the structure of lanthanide-phospholipid complex (Tm-DOPC complex). The analysis of paramagnetic properties such as the temperature sensitivity of LIS indicates the prospect of using kinetically unstable lanthanide complexes as shifting temperature-sensitive probes for determining local temperature using MRI technologies.

该研究的目的是显示Tm ³⁺可以用作脂质膜线性响应探针的极限。借助NMR光谱，以DOPC磷脂为例，研究了镧系元素诱导的化学位移（LISs）的温度依赖性。结果表明，这些依赖性具有热特征，这可能与镧系元素-磷脂复合物（Tm-DOPC复合物）的结构变化有关。对诸如LIS的温度敏感性等顺磁性质的分析表明，使用动力学不稳定的镧系元素络合物作为移动热敏探针来利用MRI技术确定局部温度的前景。