当前位置: X-MOL 学术BMC Neurosci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Autistic traits are associated with the functional connectivity of between—but not within—attention systems in the general population
BMC Neuroscience ( IF 2.4 ) Pub Date : 2020-11-23 , DOI: 10.1186/s12868-020-00603-2
Sayaka Yoshimura 1 , Kei Kobayashi 2 , Tsukasa Ueno 2 , Takashi Miyagi 2 , Naoya Oishi 3 , Toshiya Murai 2 , Hironobu Fujiwara 2, 4
Affiliation  

Background Previous studies have demonstrated that individuals with autism spectrum disorder (ASD) exhibit dysfunction in the three attention systems ( i.e. , alerting, orienting, and executive control) as well as atypical relationships among these systems. Additionally, other studies have reported that individuals with subclinical but high levels of autistic traits show similar attentional tendencies to those observed in ASD. Based on these findings, it was hypothesized that autistic traits would affect the functions and relationships of the three attention systems in a general population. Resting-state functional magnetic resonance imaging (fMRI) was performed in 119 healthy adults to investigate relationships between autistic traits and within- and between-system functional connectivity (FC) among the three attention systems. Twenty-six regions of interest that were defined as components of the three attention systems by a previous task-based fMRI study were examined in terms of within- and between-system FC. We assessed autistic traits using the Autism-Spectrum Quotient. Results Correlational analyses revealed that autistic traits were significantly correlated with between-system FC, but not with within-system FC. Conclusions Our results imply that a high autistic trait level, even when subclinical, is associated with the way the three attention systems interact.

中文翻译:

自闭症特征与普通人群中注意力系统之间(而非内部)的功能连通性有关

背景 先前的研究表明,自闭症谱系障碍 (ASD) 个体在三个注意力系统(即警报、定向和执行控制)以及这些系统之间的非典型关系中表现出功能障碍。此外,其他研究报告称,具有亚临床但高度自闭症特征的个体表现出与 ASD 中观察到的相似的注意力倾向。基于这些发现,假设自闭症特征会影响一般人群中三种注意力系统的功能和关系。对 119 名健康成年人进行静息状态功能磁共振成像 (fMRI),以研究自闭症特征与三个注意力系统之间的系统内和系统间功能连接 (FC) 之间的关系。在系统内和系统间 FC 方面检查了 26 个感兴趣区域,这些区域被先前基于任务的 fMRI 研究定义为三个注意系统的组成部分。我们使用自闭症谱商评估自闭症特征。结果 相关性分析表明,自闭症特征与系统间 FC 显着相关,但与系统内 FC 无关。结论 我们的结果表明,即使是亚临床的,高自闭症特征水平也与三个注意力系统的相互作用方式有关。结果 相关分析表明,自闭症特征与系统间 FC 显着相关,但与系统内 FC 无关。结论 我们的结果表明,即使是亚临床的,高自闭症特征水平也与三个注意力系统的相互作用方式有关。结果 相关分析表明,自闭症特征与系统间 FC 显着相关,但与系统内 FC 无关。结论 我们的结果表明,即使是亚临床的,高自闭症特征水平也与三个注意力系统的相互作用方式有关。
更新日期:2020-11-23
down
wechat
bug