Every year the Alzheimer’s Association publishes a report that provides facts and figures indicating the public health, social and economic impact of Alzheimer’s disease (AD). In addition, there are a number of reviews on the disease for general readers. Also, at congresses, AD is analyzed at different but not always related levels, leading to an “elephant as seen by blind men situation” for many of the participants. The review presented herein seeks to provide readers with a holistic view of how AD develops from various perspectives: the whole human organism, brain, circuits, neurons, cellular hallmarks, and molecular level.

中文翻译：

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阿尔茨海默病发展的多层次观点

每年，阿尔茨海默病协会都会发布一份报告，其中提供的事实和数据表明阿尔茨海默病 (AD) 对公共健康、社会和经济的影响。此外，还有一些针对普通读者的疾病评论。此外，在大会上，AD 在不同但并不总是相关的层面进行分析，导致许多参与者出现“盲人所见的大象情况”。本文介绍的综述旨在从各个角度为读者提供关于 AD 如何发展的整体观点：整个人类有机体、大脑、电路、神经元、细胞标志和分子水平。