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Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics
Cancer Letters ( IF 9.7 ) Pub Date : 2020-11-24 , DOI: 10.1016/j.canlet.2020.11.018
Susi Zhu 1 , Yeye Guo 2 , Xu Zhang 2 , Hong Liu 2 , Mingzhu Yin 2 , Xiang Chen 2 , Cong Peng 1
Affiliation  

Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, is a critical regulator in tumor metabolism. PKM2 has been demonstrated to overexpressed in various cancers and promoted proliferation and metastasis of tumor cells. The errant expression of PKM2 has inspired people to investigate the function of PKM2 and the therapeutic potential in cancer. In addition, some studies have shown that the upregulation of PKM2 in tumor tissues is associated with the altered expression of lncRNAs and the poor survival. Therefore, researchers have begun to unravel the specific molecular mechanisms of lncRNA-mediated PKM2 expression in cancer metabolism. As the tumor microenvironment (TME) is essential in tumor development, it is necessary to identify the role of PKM2 in TME. In this review, we will introduce the role of PKM2 in different cancers as well as TME, and summarize the molecular mechanism of PKM2-related lncRNAs in cancer metabolism. We expect that this work will lead to a better understanding of the molecular mechanisms of PKM2 that may help in developing therapeutic strategies in clinic for researchers.



中文翻译:

丙酮酸激酶 M2 (PKM2) 在癌症和癌症治疗中的应用

丙酮酸激酶 M2 (PKM2) 是糖酵解的关键限速酶,是肿瘤代谢的关键调节剂。PKM2 已被证明在各种癌症中过表达并促进肿瘤细胞的增殖和转移。PKM2 的错误表达激发了人们研究 PKM2 的功能和在癌症中的治疗潜力。此外,一些研究表明肿瘤组织中PKM2的上调与lncRNAs的表达改变和较差的存活率有关。因此,研究人员开始解开lncRNA介导的PKM2表达在癌症代谢中的具体分子机制。由于肿瘤微环境 (TME) 在肿瘤发展中至关重要,因此有必要确定 PKM2 在 TME 中的作用。在这次审查中,我们将介绍PKM2在不同癌症以及TME中的作用,并总结PKM2相关lncRNA在癌症代谢中的分子机制。我们希望这项工作将有助于更好地了解 PKM2 的分子机制,这可能有助于为研究人员制定临床治疗策略。

更新日期:2020-11-25
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