Five new flavanones, davidones A-E (1-5), one new isoflavonoid, cyclolicoisoflavones A₃ (8), together with seven known compounds were isolated from the petroleum ether and the ethyl acetate fractions of the roots of Sophora davidii (Franch.) Skeels. The structures of new compounds were established by 1D and 2D NMR and MS data. The absolute configuration of 1-5 was assigned by NMR calculations and comparing its experimental and calculated ECD spectra. Flavanones were the main active principles responsible for the glucose transporter 4 (GLUT-4) translocation activities of SD-PE and SD-EtOAc. Compounds 1-7 and acacetin (12) promoted GLUT-4 translocation by the range of 1.35-3.00 folds, respectively.

Keywards: Sophora davidii; Flavonoids; Antidiabetic; GLUT-4; ECD

五个新的黄烷酮，davidones AE（1-5），一个新的异类黄酮，cyclolicoisoflavones甲₃（8具有七个已知化合物是从石油醚和根部的乙酸乙酯部分分离的），一起狼牙刺（獐。）Skeels . 新化合物的结构由一维和二维核磁共振和质谱数据确定。1-5的绝对构型是通过 NMR 计算并比较其实验和计算 ECD 谱来确定的。黄烷酮是负责 SD-PE 和 SD-EtOAc 的葡萄糖转运蛋白 4 (GLUT-4) 易位活动的主要活性成分。化合物1-7和金合欢素 ( 12) 分别将 GLUT-4 易位提高了 1.35-3.00 倍。

Keywards： 槐花；黄酮类；抗糖尿病；GLUT-4; 电子病历