Cancer phototherapy has attracted increasing attention for its promising effectiveness and relative non-invasiveness. Over the past years, tremendous efforts have been made to develop better phototherapy strategies with various nano delivery systems. This review introduces cancer phototherapy strategies based on tumor blood vessels for improved therapeutic outcomes from the angle of direct tumor destruction and improved delivery process assisted with nano delivery designs. Latest directions and ideas of cancer phototherapy with translation potential are also discussed. Focusing on the double role of tumor vessels not only as an anti-tumor target but also as part of the delivery process, we highlight the crosstalk between photo-induced extensive effects and the complicated drug delivery process. Due to the heterogeneity of tumors, deeper investigations about the interconnection between tumor vessels and cancer phototherapy remain to be carried out. More delicate and intelligent nano delivery systems are expected to help realize the full potential of this therapeutic strategy.

癌症光疗因其有希望的疗效和相对无创性而受到越来越多的关注。在过去的几年中，已经做出了巨大的努力来开发具有各种纳米递送系统的更好的光疗策略。这篇综述介绍了基于肿瘤血管的癌症光疗策略，可从直接破坏肿瘤的角度改善治疗效果，并借助纳米递送设计改善递送过程。还讨论了具有翻译潜力的癌症光疗的最新方向和思想。关注肿瘤血管的双重作用，不仅将其作为抗肿瘤靶标，而且还将其作为递送过程的一部分，我们着重介绍了光诱导的广泛效应与复杂的药物递送过程之间的串扰。由于肿瘤的异质性，关于肿瘤血管与癌症光疗之间相互联系的更深入研究仍有待进行。期望更精致和智能的纳米输送系统有助于实现这种治疗策略的全部潜力。