当前位置: X-MOL 学术BBA Gene Regul. Mech. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Crosstalk of promoter and terminator during RNA polymerase II transcription cycle
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms ( IF 4.7 ) Pub Date : 2020-11-24 , DOI: 10.1016/j.bbagrm.2020.194657
Nadra Al-Husini , Scott Medler , Athar Ansari

The transcription cycle of RNAPII is comprised of three consecutive steps; initiation, elongation and termination. It has been assumed that the initiation and termination steps occur in spatial isolation, essentially as independent events. A growing body of evidence, however, has challenged this dogma. First, factors involved in initiation and termination exhibit both a genetic and a physical interaction during transcription. Second, the initiation and termination factors have been found to occupy both ends of a transcribing gene. Third, physical interaction of initiation and termination factors occupying distal ends of a gene sometime results in the entire terminator region of a genes looping back and contact its cognate promoter, thereby forming a looped gene architecture during transcription. A logical interpretation of these findings is that the initiation and termination steps of transcription do not occur in isolation. There is extensive communication of factors occupying promoter and terminator ends of a gene during transcription cycle. This review entails a discussion of the promoter-terminator crosstalk and its implication in the context of transcription.



中文翻译:

RNA聚合酶II转录周期中启动子和终止子的串扰

RNAPII的转录周期包括三个连续的步骤:引发,伸长和终止。假设起始和终止步骤在空间上隔离,基本上是独立事件。然而,越来越多的证据对这一教条提出了挑战。首先,参与起始和终止的因素在转录过程中既表现出遗传相互作用,又表现出物理相互作用。第二,已经发现起始和终止因子占据了转录基因的两端。第三,起始和终止因子占据基因远端的物理相互作用有时会导致基因的整个终止子区域环回并与其同源启动子接触,从而在转录过程中形成环状的基因结构。这些发现的逻辑解释是转录的起始和终止步骤不是孤立发生的。在转录周期中,有许多因素占据着基因的启动子和终止子末端。这篇综述需要讨论启动子-终止子的串扰及其在转录中的含义。

更新日期:2020-11-25
down
wechat
bug