Cancer is the world's devastating disease, and breast cancer is the most common reason for the death of women worldwide. Many synthetic drugs and medications are provided with their beneficial actions, but all of these have side effects and resistance problems. Natural remedies are coming forward to overcome the disadvantages of synthetic drugs. Among the natural categories, phytoestrogens having a structural similarity of mammalian oestradiol proves its benefit with various mechanisms not only in the treatment of breast cancer but even to prevent the occurrence of postmenopausal symptoms. Phytoestrogens are plant-derived compounds that were utilized in ancient medications and traditional knowledge for its sex hormone properties. Phytoestrogens exert pleiotropic effects on cellular signalling and show effects on estrogen-dependent diseases. However, because of activation/inhibition of steroid hormonal receptor ER-α or ER-β, these compounds induce or inhibit steroid hormonal (estrogen) action and, therefore, have the potential to disrupt hormone (estrogen) signalling pathway. In this review, we have discussed and summarize the effect of certain phytoestrogens and their possible mechanisms that can substantiate advantageous benefits for the treatment of post-menopausal symptoms as well as for breast cancer.

癌症是世界上毁灭性的疾病，而乳腺癌是全世界女性死亡的最常见原因。许多合成药物和药物都具有其有益的作用，但是所有这些药物都有副作用和耐药性问题。为了克服合成药物的缺点，人们正在寻求自然疗法。在自然类别中，具有哺乳动物雌二醇结构相似性的植物雌激素不仅具有治疗乳腺癌的作用，而且具有防止绝经后症状发生的多种机制，证明了其益处。植物雌激素是植物来源的化合物，由于其性激素特性而被用于古代药物和传统知识中。植物雌激素对细胞信号传导发挥多效作用，并显示对雌激素依赖性疾病的影响。但是，由于类固醇激素受体ER-α或ER-β的激活/抑制，这些化合物诱导或抑制类固醇激素（雌激素）作用，因此有可能破坏激素（雌激素）信号通路。在这篇综述中，我们已经讨论并总结了某些植物雌激素的作用及其可能的机制，这些机制可以证实绝经后症状以及乳腺癌的有益益处。