Visible-light-induced radical isocyanide insertion protocol for the synthesis of difluoromethylated spiro[indole-3,3′-quinoline] derivatives,Chemical Communications

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Visible-light-induced radical isocyanide insertion protocol for the synthesis of difluoromethylated spiro[indole-3,3′-quinoline] derivatives
Chemical Communications ( IF 4.9 ) Pub Date : 2020-11-14 , DOI: 10.1039/d0cc06645a
Jingjing Zhang _{1,

2,

3,

4,

5} , Wentao Xu _{1,

2,

3,

4,

5} , Yi Qu _{1,

2,

3,

4,

5} , Yuxiu Liu _{1,

2,

3,

4,

5} , Yongqiang Li _{1,

2,

3,

4,

5} , Hongjian Song _{1,

2,

3,

4,

5} , Qingmin Wang _{1,

2,

3,

4,

5}

Affiliation

Herein, we report the first protocol for visible-light-induced radical isocyanide insertion reactions between 3-(2-isocyanobenzyl)-indoles and bromodifluoroacetates or bromodifluoroacetamides. The protocol, which has good functional group tolerance and a broad substrate scope, constitutes an efficient and general route to difluoromethylated spiro[indole-3,3′-quinoline] derivatives.

中文翻译：

可见光诱导的自由基异氰酸酯插入方案用于合成二氟甲基化螺[吲哚-3,3'-喹啉]衍生物

在这里，我们报告了3-（2-异氰基苄基）-吲哚与溴代二氟乙酸酯或溴代二氟乙酰胺之间可见光诱导的自由基异氰酸酯插入反应的第一个协议。该协议具有良好的官能团耐受性和广泛的底物范围，构成了二氟甲基化螺[吲哚-3,3'-喹啉]衍生物的有效且通用的途径。

更新日期：2020-11-25

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