Herein, a scalable and practical process to prepare trans-4-fluorocyclohexylamine hydrochloride (1a) is described. By exploitation of the embedded gem-difluoride motif in the commercially available 4,4-difluorocyclohexanecarboxylic acid, a derived orthoester-masked acid underwent dehydrofluorination to provide the requisite vinyl fluoride for a directed hydrogenation event, enabling selective access to the trans-configuration of 1a.

中文翻译：

---

一个可扩展的综合开发跨通过定向加氢-4- Fluorocyclohexylamine

在此，描述了制备反式-4-氟环己胺盐酸盐（1a）的可扩展且实用的方法。通过利用市场上可买到的4,4-二氟环己烷甲酸中嵌入的宝石-二氟化物基序，对衍生自原酸酯掩蔽的酸进行脱氢氟化作用，以提供必要的氟乙烯用于定向氢化事件，从而能够选择性地获得1a的反式构型。