In this work, ternary phase diagrams of telmisartan-saccharin (TEL-SAC) cocrystal in methanol, ethanol, and quasi-ternary sections of the quaternary system TEL-SAC–chloroform–methanol were determined at 298.15 and 308.15 K. The results show that the stable region of cocrystal is greatly biased towards SAC in methanol and ethanol; this is due to the large solubility difference between TEL and SAC. In the mixed solvent of chloroform and methanol, the cocrystal stable region appears at the center of the whole phase diagram when the mass fraction of chloroform is 80%, which indicated that the solubility difference between TEL and SAC in the mixed solvent was relatively small. Moreover, the solubility behavior of TEL-SAC cocrystal was studied and the results showed that the solution complexation model in methanol and ethanol was 1:1 + 1:2, and the complexation model in chloroform and binary mixtures of chloroform/methanol was 1:1.

中文翻译：

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替米沙坦-糖精共晶体在298.15和313.15 K时在甲醇，乙醇和甲醇/氯仿混合物中的固液平衡和三元相图

在这项工作中，在298.15和308.15 K下确定了替米沙坦-糖精（TEL-SAC）共晶体在甲醇，乙醇和四元体系TEL-SAC-氯仿-甲醇的四元部分中的三元相图。共晶的稳定区域在甲醇和乙醇中对SAC有很大的偏倚。这是由于TEL和SAC之间的溶解度差异很大。在氯仿和甲醇的混合溶剂中，当氯仿的质量分数为80％时，共晶稳定区出现在整个相图的中心，这表明TEL和SAC在混合溶剂中的溶解度差异较小。此外，研究了TEL-SAC共晶的溶解行为，结果表明在甲醇和乙醇中的溶液络合模型为1：1 + 1：2，