This study was performed to assess the efficacy and safety of a topical diclofenac solution in patients with knee osteoarthritis (OA). PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases were searched for randomized controlled trials until June 2020. The WOMAC pain, stiffness, physical function subscales, pain on walking, and the occurrence of adverse events were pooled to comprehensively analyse the efficacy and safety of topical diclofenac solution. All statistical analyses were conducted using Review Manager 5.3 software. Five RCTs were included, which provided high-quality evidence. In comparison to the vehicle control, the mean differences for WOMAC pain, stiffness, and physical function subscales, as well as pain on walking, were all statistically significant in favor of topical diclofenac solution. The safety of topical diclofenac solution was similar to the vehicle control, apart from adverse events involving application-site skin reactions. Topical diclofenac solution is effective and safe for use in patients with knee OA, but may cause minor skin reactions.

中文翻译：

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双氯芬酸局部治疗膝部骨关节炎：随机对照试验的最新荟萃分析

进行这项研究以评估局部双氯芬酸溶液在膝骨关节炎（OA）患者中的疗效和安全性。搜索PubMed，Embase，Cochrane图书馆，Web of Science和Scopus数据库以进行随机对照试验，直到2020年6月。将WOMAC的疼痛，僵硬，身体功能分量表，行走时的疼痛以及不良事件的发生汇总起来，以进行综合分析。局部双氯芬酸溶液的疗效和安全性。所有统计分析均使用Review Manager 5.3软件进行。包括五个RCT，它们提供了高质量的证据。与媒介物对照相比，WOMAC疼痛，僵硬和身体机能分量表以及行走时疼痛的平均差异在统计学上均显着，有利于局部使用双氯芬酸溶液。除涉及应用部位皮肤反应的不良事件外，双氯芬酸局部用药溶液的安全性与溶媒对照相似。双氯芬酸局部用药溶液对膝骨关节炎患者有效且安全，但可能引起轻微的皮肤反应。