Background. Strontium ranelate (StR) is an antiosteoporotic agent previously utilized for the enhancement of fracture union. We investigated the effects of StR on fracture healing using a rabbit model. Methods. Forty adult female rabbits were included in the study and were divided in 2 equal groups, according to StR treatment or untreated controls. All animals were subjected to osteotomy of the ulna, while the contralateral ulna remained intact and served as a control for the biomechanical assessment of fracture healing. Animals in the study group received 600 mg/kg/day of StR orally. All animals received ordinary food. At 2 and 4 weeks, all animals were euthanatized and the osteotomy sites were evaluated for healing through radiological, biomechanical, and histopathological studies. Results. The treatment group presented statistically significant higher callus diameter, total callus area, percentage of fibrous tissue (), vessels/mm², number of total vessels, and lower osteoclast number/mm² () than the control group at 2 weeks. Additionally, the treatment group presented significantly higher percentages of new trabecular bone, vessels/mm², osteoclast number/mm², and lower values for callus diameter, as well as total callus area (), than the control group at 4 weeks. At 4 weeks, in the treatment group, force applied (), energy at failure (), and load at failure () were all significantly higher in the forearm specimens with the osteotomized ulnae compared to those without. Radiological bone union was demonstrated for animals receiving StR at 4 weeks compared with controls (). Conclusion. StR appears to enhance fracture healing but further studies are warranted in order to better elucidate the mechanisms and benefits of StR treatment.

中文翻译：

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雷尼酸锶对骨折愈合的影响：一项动物研究

背景。S trontium ranelate (StR) 是一种抗骨质疏松剂，以前用于增强骨折愈合。我们使用兔子模型研究了 StR 对骨折愈合的影响。方法. 40 只成年雌性兔被纳入研究，并根据 StR 治疗或未治疗对照分为 2 个相等的组。所有动物都接受了尺骨截骨术，而对侧尺骨保持完整，并作为骨折愈合生物力学评估的对照。研究组中的动物口服 600 mg/kg/天的 StR。所有动物都接受普通食物。在第 2 周和第 4 周，对所有动物实施安乐死，并通过放射学、生物力学和组织病理学研究评估截骨部位的愈合情况。结果。治疗组的愈伤组织直径、愈伤组织总面积、纤维组织百分比显着增加（)、血管/mm ²、总血管数、下破骨细胞数/mm ² ()在 2 周时优于对照组。此外，治疗组的新骨小梁百分比、血管/mm ²、破骨细胞数/mm ²的百分比显着增加，骨痂直径和骨痂总面积的值较低。)，在 4 周时优于对照组。在 4 周时，在治疗组中，施加力 (),失效能量 (),并在失败时加载 ()在有截骨的尺骨的前臂标本中均显着高于没有截骨的前臂标本。与对照组相比，接受 StR 的动物在 4 周时表现出放射骨愈合（）。 结论。StR 似乎可以促进骨折愈合，但需要进一步研究以更好地阐明 StR 治疗的机制和益处。