The current study aims to investigate the effects of micro-lens arrays (MLA) and diffractive optical elements (DOE) on skin tissue via intra-dermal laser-induced optical breakdown (LIOB) after irradiation of 1064-nm picosecond laser light at high energy settings. Irradiation with MLA and DOE was tested on dimming paper, tissue-mimicking phantom, and dark pigmented porcine skin to quantitatively compare distributions of micro-beams, micro-bubbles, and laser-induced vacuoles in the skin. DOE yielded more uniform distributions of the micro-beams on the paper and laser-induced micro-bubbles in the phantom, compared to MLA. The ex vivo skin test confirmed that the DOE-assisted irradiation accompanied more homogeneous generation of the micro-beams on the tissue surface (deviation of ≤ 3%) and a high density of small laser-induced vacuoles (∼78 µm) in the dermis than the MLA-assisted irradiation (deviation of ∼26% and ∼163 µm). The DOE-assisted picosecond laser irradiation may help to achieve deep and uniformly-generated vacuolization under the basal membrane after intra-dermal LIOB for effective fractional skin treatment.

中文翻译：

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1064 nm皮秒激光辐照后，微透镜阵列和衍射光学元件对离体猪皮肤的激光诱导光学击穿效应

当前的研究旨在通过高能量照射1064 nm皮秒激光后，通过皮内激光诱导的光学击穿（LIOB）研究微透镜阵列（MLA）和衍射光学元件（DOE）对皮肤组织的影响。设置。在调光纸，模仿组织的幻像和深色色素的猪皮肤上测试了MLA和DOE的辐射，以定量比较皮肤中微束，微气泡和激光诱导的液泡的分布。与MLA相比，DOE产生了纸上微束的更均匀分布以及体模中激光诱导的微气泡的分布。在体外皮肤试验证实，DOE辅助照射比MLA伴随着组织表面上更均匀的微束生成（偏差≤3％）以及真皮中高密度的小激光诱导液泡（〜78 µm）辅助照射（偏差约26％和约163 µm）。DOE辅助的皮秒激光辐照可以帮助在真皮内LIOB后实现基底膜下的深层和均匀生成的空泡化，以进行有效的局部皮肤治疗。