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ATE1-Mediated Post-Translational Arginylation Is an Essential Regulator of Eukaryotic Cellular Homeostasis
ACS Chemical Biology ( IF 4 ) Pub Date : 2020-11-23 , DOI: 10.1021/acschembio.0c00677
Verna Van 1 , Aaron T Smith 1
Affiliation  

Arginylation is a protein post-translational modification catalyzed by arginyl-tRNA transferases (ATE1s), which are critical enzymes conserved across all eukaryotes. Arginylation is a key step in the Arg N-degron pathway, a hierarchical cellular signaling pathway that links the ubiquitin-dependent degradation of a protein to the identity of its N-terminal amino acid side chain. The fidelity of ATE1-catalyzed arginylation is imperative, as this post-translational modification regulates several essential biological processes such as cardiovascular maturation, chromosomal segregation, and even the stress response. While the process of ATE1-catalyzed arginylation has been studied in detail at the cellular level, much remains unknown about the structure of this important enzyme, its mechanism of action, and its regulation. In this work, we detail the current state of knowledge on ATE1-catalyzed arginylation, and we discuss both ongoing and future directions that will reveal the structural and mechanistic details of this essential eukaryotic cellular regulator.

中文翻译:

ATE1 介导的翻译后精氨酸化是真核细胞稳态的重要调节剂

精氨酸化是一种由精氨酸 tRNA 转移酶 (ATE1) 催化的蛋白质翻译后修饰,ATE1 是所有真核生物中保守的关键酶。精氨酸化是 Arg N-degron 通路中的关键步骤,这是一种分层的细胞信号通路,它将蛋白质的泛素依赖性降解与其 N 端氨基酸侧链的身份联系起来。ATE1 催化的精氨酸化的保真度是必不可少的,因为这种翻译后修饰调节了几个基本的生物过程,如心血管成熟、染色体分离,甚至应激反应。虽然已经在细胞水平上详细研究了 ATE1 催化的精氨酸化过程,但关于这种重要酶的结构、作用机制和调节仍有很多未知。在这项工作中,
更新日期:2020-12-18
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