Ischemia reperfusion (IR)-induced oxidative stress, accompanied by inflammatory responses, contributes to morbidity and mortality in numerous diseases such as acute coronary syndrome, stroke, organ transplantation, and limb injury. Ischemia results in profound hypoxia and tissue dysfunction, whereas subsequent reperfusion further aggravates ischemic tissue damage through inducing cell death and activating inflammatory responses. In this review, we highlight recent studies of therapeutic strategies against IR injury. Furthermore, nanotechnology offers significant improvements in this area. Hence, we also review recent advances in nanomedicines for IR therapy, suggesting them as potent and promising strategies to improve drug delivery to IR-injured tissues and achieve protective effects.

中文翻译：

---

缺血再灌注损伤：纳米颗粒的机会

缺血再灌注（IR）诱导的氧化应激，伴随炎症反应，导致许多疾病的发病率和死亡率，例如急性冠脉综合征，中风，器官移植和肢体损伤。缺血导致严重的缺氧和组织功能障碍，而随后的再灌注通过诱导细胞死亡和激活炎症反应进一步加重了缺血性组织损伤。在这篇综述中，我们重点介绍了针对IR损伤的治疗策略的最新研究。此外，纳米技术在这一领域提供了重大改进。因此，我们还回顾了用于IR治疗的纳米药物的最新进展，表明它们是改善药物向IR损伤组织的药物递送并实现保护作用的有效且有前途的策略。