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Low rank mechanisms underlying flexible visual representations [Colloquium Papers (free online)]
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-11-24 , DOI: 10.1073/pnas.2005797117
Douglas A. Ruff 1 , Cheng Xue 1 , Lily E. Kramer 1 , Faisal Baqai 2 , Marlene R. Cohen 1, 2
Affiliation  

Neuronal population responses to sensory stimuli are remarkably flexible. The responses of neurons in visual cortex have heterogeneous dependence on stimulus properties (e.g., contrast), processes that affect all stages of visual processing (e.g., adaptation), and cognitive processes (e.g., attention or task switching). Understanding whether these processes affect similar neuronal populations and whether they have similar effects on entire populations can provide insight into whether they utilize analogous mechanisms. In particular, it has recently been demonstrated that attention has low rank effects on the covariability of populations of visual neurons, which impacts perception and strongly constrains mechanistic models. We hypothesized that measuring changes in population covariability associated with other sensory and cognitive processes could clarify whether they utilize similar mechanisms or computations. Our experimental design included measurements in multiple visual areas using four distinct sensory and cognitive processes. We found that contrast, adaptation, attention, and task switching affect the variability of responses of populations of neurons in primate visual cortex in a similarly low rank way. These results suggest that a given circuit may use similar mechanisms to perform many forms of modulation and likely reflects a general principle that applies to a wide range of brain areas and sensory, cognitive, and motor processes.



中文翻译:

灵活的视觉表示基础的低等级机制[学术论文(免费在线)]

神经元群体对感觉刺激的反应非常灵活。视觉皮层中神经元的响应对刺激属性(例如,对比度),影响视觉处理的所有阶段(例如,适应)和认知过程(例如,注意力或任务切换)的过程具有不同的依赖性。了解这些过程是否会影响相似的神经元种群,以及它们是否对整个种群具有相似的影响,可以深入了解它们是否利用类似的机制。特别是,最近已证明注意力对视觉神经元群体的协变性具有较低的等级影响,这会影响感知并强烈限制机械模型。我们假设测量与其他感官和认知过程相关的总体协方差的变化可以澄清它们是否利用类似的机制或计算方法。我们的实验设计包括使用四个不同的感觉和认知过程在多个视觉区域进行测量。我们发现,对比度,适应性,注意力和任务切换以类似的低等级方式影响灵长类动物视觉皮层中神经元群体反应的变异性。这些结果表明,给定的电路可以使用类似的机制来执行多种形式的调制,并且可能反映出适用于广泛的大脑区域以及感觉,认知和运动过程的一般原理。我们的实验设计包括使用四个不同的感觉和认知过程在多个视觉区域进行测量。我们发现,对比度,适应性,注意力和任务切换以类似的低等级方式影响灵长类动物视觉皮层中神经元群体反应的变异性。这些结果表明,给定的电路可以使用类似的机制来执行多种形式的调制,并且可能反映出适用于广泛的大脑区域以及感觉,认知和运动过程的一般原理。我们的实验设计包括使用四个不同的感觉和认知过程在多个视觉区域进行测量。我们发现,对比度,适应性,注意力和任务切换以类似的低等级方式影响灵长类动物视觉皮层中神经元群体反应的变异性。这些结果表明,给定的电路可以使用类似的机制来执行多种形式的调制,并且可能反映出适用于广泛的大脑区域以及感觉,认知和运动过程的一般原理。

更新日期:2020-11-25
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