Eosinophilic oesophagitis (EoE) is characterised by oesophageal inflammation, fibrosis and dysfunction. Micro (mi)‐RNAs interfere with pro‐inflammatory and pro‐fibrotic transcriptional programs, and miR‐223 was upregulated in oesophageal mucosal biopsy specimens from EoE patients. The therapeutic potential of modulating miR‐223 expression in vivo has not been determined. We aimed to elucidate the relevance of oesophageal miR‐223 expression in an in vivo model of EoE by inhibiting miR‐223 tissue expression.

中文翻译：

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实验性嗜酸性食管炎中 miR-223 的体内靶向

嗜酸性食管炎（EoE）的特点是食管炎症、纤维化和功能障碍。Micro (mi)-RNAs 干扰促炎和促纤维化转录程序，并且 miR-223 在 EoE 患者的食管粘膜活检标本中上调。尚未确定在体内调节 miR-223 表达的治疗潜力。我们旨在通过抑制 miR-223 组织表达来阐明 EoE体内模型中食管 miR-223 表达的相关性。